Marimastat [Usan]: Full Drug Profile
Marimastat [Usan] - General Information
Used in the treatment of cancer, Marmiastat is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.
Pharmacology of Marimastat [Usan]
Used in the treatment of cancer, it is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.
Additional information about Marimastat [Usan]
Marimastat [Usan] Indication: For the treatment of various cancers Mechanism Of Action: Marimastat [Usan] is a hydroxamic acid, matrix metalloprotease inhibitor. It mimics the peptide structure of natural MMP substrates. It binds to matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) thereby preventing the degradation of the basement membrane by these proteases. This antiprotease action prevents the migration of endothelial cells needed to form new blood vessels. Inhibition of MMPs also prevents the entry and exit of tymor cells into existing blood cells, thereby preventing metastasis. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Marimastat Synonyms: Not Available Drug Category: Antineoplastic Agents Drug Type: Small Molecule; Approved Other Brand Names containing Marimastat: Marimastat [Usan]; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Marimastat [Usan]: Not Available Chemical IUPAC Name: (2R,3S)-N-[(2S)-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide Chemical Formula: C15H29N3O5 Marimastat on Wikipedia: https://en.wikipedia.org/wiki/Marimastat Organisms Affected: Humans and other mammals