Marimastat [Usan]

Marimastat [Usan] - General Information

Used in the treatment of cancer, Marmiastat is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.

Pharmacology of Marimastat [Usan]

Used in the treatment of cancer, it is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.

Additional information about Marimastat [Usan]

Marimastat [Usan] Indication: For the treatment of various cancers
Mechanism Of Action: Marimastat [Usan] is a hydroxamic acid, matrix metalloprotease inhibitor. It mimics the peptide structure of natural MMP substrates. It binds to matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) thereby preventing the degradation of the basement membrane by these proteases. This antiprotease action prevents the migration of endothelial cells needed to form new blood vessels. Inhibition of MMPs also prevents the entry and exit of tymor cells into existing blood cells, thereby preventing metastasis.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Marimastat
Synonyms: Not Available
Drug Category: Antineoplastic Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Marimastat: Marimastat [Usan];
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Marimastat [Usan]: Not Available
Chemical IUPAC Name: (2R,3S)-N-[(2S)-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide
Chemical Formula: C15H29N3O5
Marimastat on Wikipedia: https://en.wikipedia.org/wiki/Marimastat
Organisms Affected: Humans and other mammals